Genomic approaches to human genetics; variability of gene expression; systems biology of disease; theory of canalization and biological robustness.
A generally overlooked aspect of biological systems is their robustness. Development, behavior and physiology for the most part operate within some normal range and are resistant to environmental or mutational perturbation. Humans in particular evolved rapidly and have dramatically altered their own environment in recent generations. My group is interested in the question of whether and how these perturbations contribute to complex diseases like metabolic syndrome, cancer, and depression.