Wallace H. Coulter Distinguished Faculty Chair in Biomedical Engineering
My group studies the bioinformatics of gene regulation. The four main directions of research that we work on are cis-regulatory code (how to decipher non-gene sequences in DNA), cancer informatics, behavioral neurogenomics and evolution of gene regulation. We work on fundamental bioinformatics problems relevant to all of these directions, including multi-omics integration, single-cell analysis, variant interpretation, and gene regulatory network inference.
Our work explores the molecular basis of diverse biological processes of great scientific interest, including embryonic development, cancer drug response, and social behavior. We develop innovative computational methods, based on probabilistic inference, machine learning, and biophysics-inspired models, to analyze heterogeneous biological data sets in search for answers to pressing biological questions. We collaborate extensively with experimental biologists for confirmation of predictions made by our models.