Yes

Koonin's principal research goals include the comparative analysis of sequenced genomes and automatic methods for genome-scale annotation of gene functions.[3] His research also investigates the application of comparative genomics for phylogenetic analysis, reconstruction of ancestral life forms and building large-scale evolutionary scenarios, as well as mathematical modeling of genome evolution.[4][5][6] Koonin's research also investigates computational study of the major transitions in the evolution of life (such as the origin of eukaryotes), the evolution of eukaryotic signalin